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Mostra il contenuto di CRS4 Articolo per Autore "Bongcam-Rudlof, Erik"
High-throughput technologies, such as next-generation sequencing, have turned molecular biology into a
data-intensive discipline, requiring bioinformaticians to use high-performance computing resources and carry out
data management and analysis tasks on large scale. Workflow systems can be useful to simplify construction of
analysis pipelines that automate tasks, support reproducibility and provide measures for fault-tolerance. However,
workflow systems can incur significant development and administration overhead so bioinformatics pipelines are
often still built without them. We present the experiences with workflows and workflow systems within the
bioinformatics community participating in a series of hackathons and workshops of the EU COST action SeqAhead.
The organizations are working on similar problems, but we have addressed them with different strategies and
solutions. This fragmentation of efforts is inefficient and leads to redundant and incompatible solutions. Based on our
experiences we define a set of recommendations for future systems to enable efficient yet simple bioinformatics
workflow construction and execution.