Inferring the functional role of microRNAs from gene expression data

dc.contributor.author	Uva, Paolo
dc.date.accessioned	2014-05-14T08:21:24Z
dc.date.available	2014-05-14T08:21:24Z
dc.date.issued	2012-07-11
dc.description	Collana seminari interni 2012, Number 20120704.	IT
dc.description.abstract	MicroRNAs are short non coding RNA sequences that have emerged as a key mechanism for the regulation of a wide range of biological processes by targeting multiple genes for degradation and translation inhibition. Although new microRNAs are continually discovered, the biological role of most of them still remains unclear. One major challenge for the comprehension of miRNA functions resides in the prediction of target mRNAs, which is generally based on physical and evolutionary properties of the target sites. In this seminar, the functional role of miRNAs and the computational strategies for the identification of their putative targets will be described. As a case study, we will show the results obtained from an integrated analysis of miRNA-target expression data collected during the cellular differentiation process.	IT
dc.identifier.uri	http://hdl.handle.net/11050/896
dc.language.iso	en	IT
dc.subject	microRNAs	IT
dc.subject	miRNA	IT
dc.subject	disease	IT
dc.subject.een-cordis	EEN CORDIS::SCIENZE BIOLOGICHE ::Ricerca sul genoma ::Bioinformatica	IT
dc.subject.program	Program::Biomedicine::Bioinformatics (BI)	IT
dc.title	Inferring the functional role of microRNAs from gene expression data	IT
dc.type	Contributo a convegno	IT

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